Pioneer Works is a multidisciplinary cultural center, often likened to a nightclub for the avant-garde, located in the Red Hook neighborhood of Brooklyn, New York. Founded in 2012 by artist Dustin Yellin, the venue occupies a sprawling 25,000-square-foot brick warehouse dating back to 1866, which was originally used as an iron works factory. Over the years, Pioneer Works has cultivated a reputation as a vibrant crossroads for contemporary music, visual arts, technology, and experimental performance, distinguishing itself as a space where art and community intersect late into the night.

While it is not a traditional nightclub in the strictest sense, many of its music and performance programming take on the energy of a club space, featuring DJ sets, live music, and immersive sound and light installations that run into the early hours, promoting a spirit of innovation and inclusivity. Pioneer Works has remained at its original location on Pioneer Street, but its interior has seen significant renovations and adaptive reuse. The founders and curators have continually reimagined the space, maintaining its industrial rawness while adding new studios, exhibition areas, technological laboratories, and a garden, encouraging cross-disciplinary collaboration.

The institution is known for its residency programs and public events, drawing local and international talent to its unique stage. Over time, its distinct approach to programming—blending art, science, and music—has made it a cultural beacon in New York City's creative landscape, frequently cited as a hub for emerging and established artists to experiment outside the constraints of commercial galleries or mainstream clubs. Its cultural significance is heightened by its role in building community through education, accessibility, and fusion of genres that rarely share the same stage.

Among the many notable artists who have performed or presented work at Pioneer Works are internationally acclaimed musicians and DJs like Laurie Anderson, Arca, Dev Hynes (Blood Orange), FKA twigs, and William Basinski, as well as influential groups such as the Sun Ra Arkestra. Local talents and experimental acts including Yuka C Honda, Greg Fox, and the Red Hook Jazz Project have also graced its events. The venue has hosted multidisciplinary happenings with innovative collectives like Discwoman and RVNG Intl., bridging the gap between music, technology, and visual art for an ever-evolving audience.