Arcana is a distinctive nightclub located in Durham, North Carolina, known for its eclectic atmosphere and dedication to showcasing diverse genres of electronic, jazz, and experimental music. Established in 2016, Arcana quickly became a cornerstone of Durham’s nightlife, celebrated for its unique, moody interior inspired by mysticism and the tarot, an homage reflected not just in its name but in the decor and cocktail menu. Initially, Arcana operated as a "cocktail and tarot bar," integrating regular tarot readings and themed nights, which drew an eclectic crowd ranging from university students to art community mainstays.

Over the years, Arcana has cultivated a reputation as a safe, inclusive, and vibrant space for marginalized and LGBTQ+ communities, prioritizing events that center on inclusivity, mutual respect, and the showcasing of both up-and-coming and established talent. Though relatively young, Arcana’s cultural significance is marked by its role as an incubator for Durham’s burgeoning underground music scene and its support of local visual artists through regular exhibitions. While Arcana’s original structure and intimate basement location remain unchanged to preserve its signature mystique, it has adapted to the evolving live music landscape by upgrading its sound system and expanding its event programming, including poetry readings, burlesque nights, immersive theater, and thematic DJ sets.

Notable artists who have performed at Arcana include local acts like DJ Shahzad and Durham’s own Electronic Ensemble, alongside nationally acclaimed performers such as DJ Minx and internationally recognized experimental artists like Aurora Halal and Umfang, who have graced the decks at special events. The club has also hosted notable jazz musicians, including Al Strong and regional collectives like The Onyx Club Boys, further cementing Arcana’s reputation as a premier site for forward-thinking music and cultural expression in the United States.